MyBioSource.com's IL15Ra antibody is a Mouse monoclonal antibody. The IL15Ra antibody was generated using CD215, and IL15RA as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
Mouse monoclonal IL15Ra antibody
The JM7A4 monoclonal antibody reacts with the IL-15 receptor alpha chain. IL-15 and IL-2 are cytokines with overlapping, but distinct, biologic effects. Their receptors share 2 subunits, the IL2R-beta and -gamma chains, which are essential for signal transduction. The IL-15R- alpha receptor is structurally related to IL-2R- alpha. However, the IL-15R alpha alone binds IL-15 with a 1,000-fold higher affinity than that seen with IL-2R- alpha and IL-2. In the human, 3 differentially spliced human IL15R- alpha variants that are all capable of high affinity binding of IL-15 have been isolated. The cytoplasmic domain of IL15R- alpha, like that of IL2R- alpha, is dispensable for mitogenic signaling, suggesting that the primary role of the alpha chains is to confer high affinity binding. At high concentrations, IL-15, like IL-2, is able to signal through a complex of IL2R-beta and IL2R-gamma in the absence of the alpha subunit